Having seen quite a few American made animated movies, Titan A.E. is definitely one of the few that manages to stand on its own as a movie. By far, this feature manages to integrate 2D and 3D animation together (almost) seamlessly. Although not perfect yet, it is a great accomplishment in the animation arena. It takes a LOT of hard work to get it to look this good. The space ships and space scenes were pretty cool.
The story is pretty simple and straightforward: an alien race called the Drej feel the human race is a threat so they decide to destroy humankind. The only hope for the survival of the human race is a ship called the Titan. The trouble is, nobody knows where it's hidden. Like most scifi movies, the plot is predictable, which is just fine for popcorn-munching entertainment, although a few unexpected twists provide for a few "Hmmm, interesting" remarks. The characters had good enough depth for a movie of this type, although I thought that the dialogue could have been written better.
Conclusion: A wonderfully entertaining movie. It's an animated piece, so leave your sense and expectations of conventional film reality behind and simply appreciate the artistic animation work. I give it a 9/10.