According to news from the Spider-Man Hype! site, Tobey Maguire, who will be playing Spider-Man himself in Sam Raimi's upcoming film, told Italian journalists that Alicia Witt is definitely in the running the path to play Peter Parker's girlfriend, Mary Jane.
On a different note, Maguire commented that filmmakers are having trouble casting the role of the villainous Green Goblin. Originally, John Malkovich was supposed to play the role, but it's unclear whether Malkovich is leaving the project.
Earlier this month, Raimi confirmed that Malkovich was the choice for the role of the villain (a.k.a. Norman Osborn). Hopefully that'll still ring true, because Malkovich just has the perfect "freaky" guy aura surrounding him. The film is marked for a January 2001 production start.