How do you stop a unmanned train cruising at high speed straight into a highly populated area? To make matters worse, this train with no air breaks carries a long cargo of toxic chemicals that threatens to wipe out an entire town when it derails or when it collides with other incoming trains that would cross its path. That's what an engineer and his conductor tries to figure out in this higly anticipated movie.

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With time and the odds all against them, they must come up with an ingenious, flawless plan to put the train to a stop without causing any of the chemicals from spilling or exploding, and they must put it in motion real soon before everything becomes too late.